GLORY RIDGE PRESENTS EDUCATION
ON
Coccidiosis Prevention in Canine
Parasite and Common Canine Disease Control
Notes Updated 1/12/2017


Print off and give to your vet if he won't give you a prescription.
I have used these treatments for years on 100's of puppies
I am NOT a veterinarian, just an experienced dog breeder.
I do not know about any other animal.


EVERY KENNEL HAS COCCIDIA!
1 EGG DIVIDES INTO 10'S OF 1000'S OF COCCIDIA. IT SHEDS THE VIRUS TO all PUPPIES.
Immature form lines the gut and ruptures cells in gut and causes severe disease.
Just as you vaccinate for PARVO and DISTEMPER (which is back in the USA with a VENGEANCE)
you MUST PREVENT COCCIDIA or NONE of your vaccines will work!
Your pups will be SMALL, loose stamina due to anemia and get pneumonia.
You can't get rid of coccidia in a kennel. It is a very tough parasite. But these pups will NOT get coccidia if you give this religiously. At 12 weeks dogs get natural immunity to this parasite, so there is NO need to use it over 12 weeks. It will NOT KILL coccidia if they have it and it is showing itself in symptom. You HAVE to PREVENT the growth in their system until the build natural immunity.

COMMON QUESTIONS/ VET ANSWERS
Q: I've been battling bloody stools in my 13 week old puppies for weeks, we have treated them with all the regularly prescribed antibiotics. Nothing has been found in the stools I've taken to my vet.
Dr. Page: You need a complete physical of your puppies, and a fecal sample taken in the clinic office. A single sample does not necessarily tell you anything, you may have to test several puppies on several different days to find the problem from samples taken in the office. You might try panacur at 1cc per 4 1/2# body weight for 3 days, and repeat in one week. Give Tribrissen or Primor daily for 14 days as per their suggested dosage.

Q: So there is no cure for coccidiosis?
Dr. Page: No there is no cure for coccidiosis. Once you see the signs of diarrhea the coccidia has done its damage and left the puppy, so all you are treating the puppy for is the symptoms of coccidia and giving antibiotics for bacterial infections.

Q: Do puppies out-grow Coccidiosis?
Dr. Page: Yes, as puppies get past 10 to 12 weeks of age they develop a natural immunity to coccidia and do not show illness if exposed as a young puppy.

NOTE FROM KAREN ON COCCIDIA
Our dogs are guaranteed against coccidia (stress diarrhea) because we medicate for prevention.
STRESS causes this problem and it can be TOTALLY PREVENTED IF YOU medicate for it. 
COCCIDIA is DEADLY and can cause DEATH in young pups. 
It is expensive to treat. ($200+ a tube) BUT saving ONE pup recoups the cost.
AGE has NOTHING to do with it not effecting the pup. If you are sent a pup with it, they will GIVE IT to all your other dogs and cats. You will have HUGE vet bills. ONLY STEAM, fire or ammonia will kill it. Ammonia is dangerous to lungs, as with bleach.
OXINE is a GOOD, SAFE disinfectant, but will not get rid of coccidia 100%.
Getting a pup at 12 weeks is NO GUARANTEE you will not get it if the dog is not properly medicated against coccidia.
****Your vaccines will not work if the dog is infected.****
COCCIDIA HAS nothing TO DO WITH FILTH, like some vets will tell people. 
It is a CONTAGIOUS parasite causing intestinal damage like parvo.


IT PREVENTS the coccidia growth in puppies system until they build natural immunity at around 12 weeks. 
I have found pups are bigger and stronger since giving this Rx. 
Runts survive 9 out of 10 times if no internal defect. I HIGHLY recommend this Rx. 
REMEMBER:
Marquis will NOT kill full blown coccidia, only PREVENT it from an outbreak.
Coccidia has a 28 day life span as a parasite.
Marquis works 21 out of 28 days. It is no good for e-coli infections.
You must kill e-coli with antibiotics .
NOTE: DO NOT USE ALBON and MARQUIS together.
If you gave ALBON today, DO NOT give Marquis today.COCCIDIOSIS PREVENTION:

SULFADIMETHOXINE
12.5 TO 25 MG/lb DAILY FOR 28 DAYS
DOGS HATE THE TASTE AND DO NOT WILLINGLY DRINK THE STUFF.

or
Albon Suspension (Rx)
1cc per 2-4 LBS Daily
EXPENSIVE AND TIME CONSUMING, but dogs don't mind the taste.
Albon will kill coccidia, but it must be given 28 days: 10 on, 8 off, 10 on.
You have to use ALBON to KILL coccidia once the PUPPY has signs of it. Adults can overcome it with a few days of Albon.
MARQUIS WILL NOT WORK ONCE SYMPTOMS of coccidia MANIFEST.


or
Albon 12 1/2% Solution
1cc per 5-10 LBS Daily
.5-10 cc (1/2 tsp) per gallon drinking water.
DOGS HATE THE TASTE AND DO NOT WILLINGLY DRINK THE STUFF.
NOTE; DO NOT GIVE SMZ TO BRACIALCEPHALIC DOGS AS IT MAY RUIN THE TEAR DUCTS.

THE BEST PREVENTATIVES:

MARQUIS
("Mar-Key") 
This is an Equine product (paste) for protozoa.
Many USDA and other Kennels are using it for dogs, successfully.
Marquis is a paste that is very expensive, but does many litters.

MARQUIS will NOT KILL coccidia if they have an outbreak and it is showing 
If you need to give ALBON for Coccidia, it is TOO LATE to use MARQUIS. Continue the Albon as prescribed. 

This information is taken from notes and experience of a nationally know veterinarian who is deep into care and research of canine disease's, and my own experience for over 5 years using this drug.
The Manufacturer's of MARQUIS take NO responsibility for this information due to incomplete FDA testing regulations.
It is NOT USDA approved for canine. Breeders have been using it in Europe for a longer time than US Breeders.


[Image of MARQUIS, the BEST Prevention for Coccidia!]
CLICK ON MARQUIS tube to link to Purchase from VET Supplier 
ANOTHER Supplier: Avenue Vet Clinic sells Marquis already MIXED BY THE CC.
Their number is 1-800-642-6594 OR 712 722-2522
YOU NEED A PRESCRIPTION FROM YOUR VET
This is good if you have a small kennel and don't need a lot.
It is very difficult to mix (like toothpaste) and may be worth the
money to have them mix it.

MARQUIS DOSAGE:

Small Breed puppies up to 10 weeks of age:
Mix 1 part paste to 3 parts distilled water and give 1cc per 2.5-3.5 lbs
Give Day 4, then 2,4,6,8 and 10 weeks of age by mouth.
Under 8 weeks Larger Breeds give 1cc straight paste per 15 lbs of puppy
Give Day 4, then 2,4,6,8 and 10 weeks of age by mouth.
Over 10 weeks old give 1cc per 10lbs week 11, week 13 and week 15


Coccidia is a very tough parasite, but these pups will NOT get coccidia if you give this religiously. 
Coccidia will quickly cause anemia and pneumonia and any secondary infections possible, quickly killing puppies.
If you have coccidia and are treating with ALBON, they also need an antibiotic such as Clavomox. 


"DO NOT GIVE CORID. CORID IS TOXIC AT WRONG DOSAGE." PER DR. PAGE DVM
Some Breeders are now using BAYCOX (much cheaper)instead of Marquis and are reporting very good 
results. As I get more information, I will report it here. If you have experience with it, please email
me at gloryridge2003@yahoo.com

PARASITE CONTROL

Worm with PYRAN 50 EVERY WEEK starting at week one until weaned 
1cc per 10lbs 
Waiting 2 weeks can KILL a PUP from HOOKS. 
Hook larva are in Mom's milk! They are released from muscles of stressed moms.

THEN
Be Sure to use PANACUR OR STONGID T
at weaning for 3 days and repeat in 2 weeks to kill GIARDIA 100%. 
Flagyl can cause LIVER DAMAGE. I do NOT use it.
EXTERNAL PARASITE PREVENTION:
Use Ivomectin POUR_ON (oil based) EVERY 14 days.
Apply to skin down back.
Start at 2-3 weeks. WILL NOT KILL whip worms.
Large Dogs use 1cc per 14-22 lbs down back ON SKIN.
Small Dogs: 1 part Ivomectin to 1 part 70% alcohol then 1cc per 7-11 lbs

Puppies: 1 part Ivomectin to 5 parts 70% rubbing alcohol does 6 drops per pound of puppy on back skin
or 3/10 cc per lb.

Give RABIES according to State law.

HEART WORM PREVENTION FORMULA:
You MUST TEST for heart worm BEFORE you give Ivermectin to a dog or
you will KILL it if it HAS ADULT heartworms.
IVOMECTIN will KILL HERDING DOGS ALSO with or without heartworm.

2/10TH CC IVERMECTIN 1 % + 30 CC PYRAN 50
DOSE: 1CC PER 20 LBS by MOUTH EVERY 30 DAYS

If a dog has heartworm and a misquote bites it and goes and bites another dog, it WILL pass
the heartworms. TEST and MEDICATE ALL YOUR DOGS.

COMMON CANINE DISEASE CONTROL

We use NEOPAR PARVO Vaccine. The ONLY Vaccine for PARVO that overrides maternal antibodies.

Manufacturer recommend dosage:
NEOPAR Parvo vaccine at 35 days, 49 days old, 10 weeks.
Add NEOVAC DA2 at 42 days, 56 days, 10 weeks and 14 weeks of age.
Adults vaccinate once a year when NOT PREGNANT.
Pups die of PARVO between 6-8 weeks. 
Give nutrical or dyne to KEEP the small pups SUGAR UP when stressed from the shot.
Do not vaccinate sick pups.

DO NOT GIVE CORONA AT ALL. THE VACCINE DOES NOT WORK.
Only pups under 2 weeks old are effected by CORONA.
The chemical put in the vaccine will act as a blocker of any other vaccine for 3 weeks.
The dead vaccine WILL NOT stop the disease. 
Parainfluenza is NOT needed. 
Do NOT use Lepto, Da1 in PARTIAL DOSES. Do not give lepto before 16 weeks.
Kennel Cough: use INTRANASAL, one dose only, but remember inject able antibiotics interfere with the vaccine.
You can cut water BY 1/2 before MIXING.

SOURCES:
Dr. Bob Page DVM 731-364-3115 Expert on Coccidia and Developer of NEOPAR
Suppliers of Marquis: 
Avenue Vet Clinic 712 722-2522 
Argimed 573 -769-2611
Iowa Vet Clinic 800-642-6594

​CURING COCCIDIA

The dose of Toltrazuril (Compare to the active ingredients of Baycox 5%®) is 20 mg/kg (10 mg per pound). This is 0.2 ml per pound of cat when using the 5% suspension. In a published study, a single dose of Toltrazuril (Compare to the active ingredients of Baycox 5%®) cured coccidiosis in puppies, as long as adequate environmental clean-up is performed. However, I'd recommend repeating it weekly for a couple of weeks. Clean up of the environment is critical to get rid of coccidia. This drug works best when it is used at the age of 4-6 weeks to PREVENT coccidia infection in kittens.

An alternative to Toltrazuril (Compare to the active ingredients of Baycox 5%®) is the similar drug ponazuril, marketed as Marquis paste for horses. The dose is 20mg/kg once a day for 1-3 days. The paste contains 150mg ponazuril per gram of paste. The plunger is marked for horses weighing 600 - 1200 pounds. You want to take the amount for a 600# horse
and dilute it to a total volume of 14 ml in something tasty. Dose at 0.1 ml per pound of cat. Discard the unused volume.
         
Here is the journal abstract I posted to the Fanciershealth Yahoogroups list in 2001: Toltrazuril treatment of cystoisosporosis in dogs under experimental and field conditions. A Daugschies, HC Mundt, V Letkova Parasitology Research, 2000, Vol 86, Iss 10, pp 797-799

Coccidia of the genus Cystoisospora cause mild to severe diarrhoea in dogs. The effects of toltrazuril treatment on cystoisosporosis were studied under experimental and field conditions. Twenty-four puppies were experimentally infected each with 4 x 10(4) oocysts of the Cystoisospora ohioensis group. Three groups of six puppies were treated 3 dpi with 10, 20 or 30 mg/kg body weight of toltrazuril suspension (5%); the remaining six puppies served as non-treated controls. Toltrazuril suspension or microgranulate were given once in a dose of 10 or 20 mg/kg body weight, respectively, to naturally infected puppies in conventional dog breeding facilities, depending on the coproscopical evidence of infection. Oocyst excretion and clinical data were recorded.

Under experimental conditions, the non-treated puppies excreted oocysts beginning at 6 dpi and suffered from catarrhalic to haemorrhagic diarrhoea. On 12 dpi, four of six non-treated puppies died. Irrespective of the dose, toltrazuril treatment totally suppressed oocyst excretion and no diarrhoea or other signs of disease were observed in the treated groups. Natural Cystoisospora infections were regularly found during the 3rd or 4th week of age in dog breeding facilities although not always associated with diarrhoea. A single oral application of toltrazuril abrogated oocyst shedding and the treated puppies remained generally coproscopically negative during the following 2-4 weeks.

Cystoisospora is pathogenic for puppies and can induce severe disease. Natural infections are common in conventional dog breeding facilities. Toltrazuril treatment is suitable for controlling cystoisosporosis under experimental and field conditions. A single oral treatment for puppies in the 3rd/4th week of age is recommended.

Here is some information directly from Dr. Bruce Kilmer at Bayer Canada:
  
The drug active is toltrazuril, which has a cidal mode of action on protozoan. The toltrazuril will kill all single cell stages of coccidiosis. Once an animal has diarrhea and you can find oocysts on fecals, the drug can not penetrate the oocysts so technically it is too late to treat. In the actual clinical cases, treatment is still worthwhile to shorten the length and severity of the diarrhea as there is still development of the life cycle in the small intestine that will be controlled.

The idea is to dose the cat before there are clinical signs. For example, the normal situation would be a cattery having regular problems with coccidiosis in young kittens. The kittens normally would break with diarrhea at about 5 weeks of age. The treatment would be given around day 28, killing the early stages of the protozoa and preventing clinical disease. You will not have the history on a rescue cat so treatment would be best at the earliest hint of an outbreak and then repeat treatment in 7 days.

Toltrazuril (Compare to the active ingredients of Baycox 5%®) treatment will not cause sloughing of the intestinal epithelial cells. The coccidiosis does a fine job of that on its own. We have electron micrograph studies of sections of intestine 24 hours post treatment with Toltrazuril (Compare to the active ingredients of Baycox 5%®). The intestinal cells remain intact and functional while the single cell stages of the cocci are dead, as evidenced by staining techniques. because Toltrazuril (Compare to the active ingredients of Baycox 5%®) is cidal, the kitten does not have to depend on its immune system to eliminate the cocci as what would occur with a static drug like sulfadimethoxine.

Remember that Toltrazuril (Compare to the active ingredients of Baycox 5%®) should be given during the preclinical stage. This is very difficult to judge as the kitten will be at a stage when it is infected but the cocci are only in the first stages of their life cycle. The intent is to kill the protozoa before there is damage to the villi to clear the infection. In this way, the kittens will not develop the normal clinical signs of diarrhea. If you can identify oocysts on fecal exam, the damage has already been done and the protozoa has completed its reproductive cycle. Drug can not penetrate the oocyst wall to kill this stage. Treatment at the first signs of a clinical case will still help to limit the severity and duration of the infection as the Toltrazuril (Compare to the active ingredients of Baycox 5%®) will kill the single cell stages that have not reproduced sexually yet.

Try to determine the usual age that you see outbreaks. For example, many catteries will see diarrhea sometime around day 35. The time to treat is therefore at day 28. Likely the kittens had an infective dose of oocysts by this stage but minimal damage has occurred. Treatment will eliminate the coccidiosis before there is damage and the kittens will not break with diarrhea. Studies in other species indicate that the animal will have developed immunity to subsequent exposure.

The dose is 20 mg/kg by oral dosing.

Toltrazuril is quite lipid soluble so absorption and distribution into tissue is very good. Toltrazuril (Compare to the active ingredients of Baycox 5%®) has a unique mode of action and there is no reason to be concerned with an adverse reaction or a drug-drug reaction. We have never had an adverse reaction reported after millions of treatments, often concurrent with other medications.

I have never heard of any adverse reactions to treatment at this dose in puppies or kittens or on the repeat seven days later. As Toltrazuril (Compare to the active ingredients of Baycox 5%®) only has activity against protozoa, there is no effect on upset of intestinal flora and the formulation is very well tolerated. The only time I have heard of any reaction occurred when someone used the Toltrazuril (Compare to the active ingredients of Baycox 5%®) 2.5% Poultry Concentrate by direct oral dosing in 3 day old piglets. This formulation is designed to be diluted in the drinking water for poultry. To be soluble in water, the product undiluted is very alkaline, pH 11.4. Direct oral dosing of the undiluted product is very irritating to mucous membranes and will cause immediate vomiting. Make sure you are using the correct formulation.
For use as a supplemental source of Vitamins & Amino Acids in horses, cattle, sheep, swine camels, alpacas, and pigeons.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
 
    
The drug active is toltrazuril, which has a cidal mode of action on protozoan. The toltrazuril will kill all single cell stages of coccidiosis. Once an animal has diarrhea and you can find oocysts on fecals, the drug can not penetrate the oocysts so technically it is too late to treat. In the actual clinical cases, treatment is still worthwhile to shorten the length and severity of the diarrhea as there is still development of the life cycle in the small intestine that will be controlled.

The idea is to dose the cat before there are clinical signs. For example, the normal situation would be a cattery having regular problems with coccidiosis in young kittens. The kittens normally would break with diarrhea at about 5 weeks of age. The treatment would be given around day 28, killing the early stages of the protozoa and preventing clinical disease. You will not have the history on a rescue cat so treatment would be best at the earliest hint of an outbreak and then repeat treatment in 7 days.

Toltrazuril (Compare to the active ingredients of Baycox 5%®) treatment will not cause sloughing of the intestinal epithelial cells. The coccidiosis does a fine job of that on its own. We have electron micrograph studies of sections of intestine 24 hours post treatment with Toltrazuril (Compare to the active ingredients of Baycox 5%®). The intestinal cells remain intact and functional while the single cell stages of the cocci are dead, as evidenced by staining techniques. because Toltrazuril (Compare to the active ingredients of Baycox 5%®) is cidal, the kitten does not have to depend on its immune system to eliminate the cocci as what would occur with a static drug like sulfadimethoxine.

Remember that Toltrazuril (Compare to the active ingredients of Baycox 5%®) should be given during the preclinical stage. This is very difficult to judge as the kitten will be at a stage when it is infected but the cocci are only in the first stages of their life cycle. The intent is to kill the protozoa before there is damage to the villi to clear the infection. In this way, the kittens will not develop the normal clinical signs of diarrhea. If you can identify oocysts on fecal exam, the damage has already been done and the protozoa has completed its reproductive cycle. Drug can not penetrate the oocyst wall to kill this stage. Treatment at the first signs of a clinical case will still help to limit the severity and duration of the infection as the Toltrazuril (Compare to the active ingredients of Baycox 5%®) will kill the single cell stages that have not reproduced sexually yet.

Try to determine the usual age that you see outbreaks. For example, many catteries will see diarrhea sometime around day 35. The time to treat is therefore at day 28. Likely the kittens had an infective dose of oocysts by this stage but minimal damage has occurred. Treatment will eliminate the coccidiosis before there is damage and the kittens will not break with diarrhea. Studies in other species indicate that the animal will have developed immunity to subsequent exposure.

The dose is 20 mg/kg by oral dosing.

Toltrazuril is quite lipid soluble so absorption and distribution into tissue is very good. Toltrazuril (Compare to the active ingredients of Baycox 5%®) has a unique mode of action and there is no reason to be concerned with an adverse reaction or a drug-drug reaction. We have never had an adverse reaction reported after millions of treatments, often concurrent with other medications.

I have never heard of any adverse reactions to treatment at this dose in puppies or kittens or on the repeat seven days later. As Toltrazuril (Compare to the active ingredients of Baycox 5%®) only has activity against protozoa, there is no effect on upset of intestinal flora and the formulation is very well tolerated. The only time I have heard of any reaction occurred when someone used the Toltrazuril (Compare to the active ingredients of Baycox 5%®) 2.5% Poultry Concentrate by direct oral dosing in 3 day old piglets. This formulation is designed to be diluted in the drinking water for poultry. To be soluble in water, the product undiluted is very alkaline, pH 11.4. Direct oral dosing of the undiluted product is very irritating to mucous membranes and will cause immediate vomiting. Make sure you are using the correct formulation.
For use as a supplemental source of Vitamins & Amino Acids in horses, cattle, sheep, swine camels, alpacas, and pigeons.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
 
  

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